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Updated: Feb 27, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Published on: December 16, 2021

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炎症性肠病诱导的炎症增加了通过Ref-1的不确定潜力的克隆性血液形成

Ramesh Kumar1, Linke Li2, Sarah Urbut3

  • 1Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.

Blood
|February 26, 2026
PubMed
概括

不确定潜力的克隆性血液形成 (CHIP) 与炎症性肠病 (IBD) 风险增加有关,特别是在女性中. 一个CHIP小鼠模型显示IBD恶化,但一种特定的抑制剂改善了结果.

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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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