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细胞衰老中的神经内分泌相关表观遗传因素:机制和治疗影响

Selvaraj Jayaraman¹, Anupriya Eswaran², Ponnulakshmi Rajagopal³

¹Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India. selvarajj.sdc@saveetha.com.

|February 26, 2026

概括

神经内分泌因素和表观遗传变化驱动细胞衰老和衰老. 通过激素和表观遗传疗法准这些途径,可能会提供减缓衰老和改善健康的策略.

科学领域:

老年学和表观遗传学
神经内分泌学神经内分泌学
细胞生物学细胞生物学

背景情况:

衰老涉及由于分子损伤导致的细胞和组织功能障碍.
细胞衰老是衰老的一个关键标志,其特点是不可逆转的细胞循环停止和细胞功能改变.
神经内分泌信号和表观遗传调节对于控制衰老和衰老至关重要.

研究的目的:

通过神经内分泌相关的表观遗传机制来审查细胞衰老的调节.
突出这些机制对与年龄有关的疾病的影响.
探索针对这些途径的新兴治疗策略.

主要方法:

文献综述侧重于神经内分泌信号,表观遗传修饰和细胞衰老.
激素调节 (HPA轴,IGF-1) 和表观遗传漂移 (DNA甲基化,基因素修饰) 的分析.
检查治疗干预措施,如表观遗传药物.

主要成果:

神经内分泌失衡 (例如,高葡萄糖皮质类药物,降低IGF-1) 加剧了衰老.
荷尔蒙变化破坏表观基因组功能,通过染色体重塑,基因组修饰和DNA甲基化加速衰老.
慢性压力激活HPA轴,导致基因组不稳定性和线粒体功能障碍.

结论:

神经内分泌失衡和表观遗传漂移是衰老的关键调节者.
表观遗传疗法 (例如,DNMT和HDAC抑制剂) 与激素调节相结合,有望延迟衰老.
了解这些途径对于开发针对年龄相关疾病的精准医学方法至关重要.

关键词:

年龄化衰老衰老疾病疾病表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.激素这些激素.神经内分泌轴的神经内分泌轴衰老是一种衰老.治疗方法治疗方法

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