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产前暴露于绿色,空气污染和温度以及早产婴儿的结果

Alice Aveline¹, Nicole Bando², Mohammad Noaeen^3,4

¹Neonatal Medicine Research Group, Imperial College London, London, United Kingdom.

JAMA network open

|February 26, 2026

概括

高臭氧和低温等环境暴露会影响早产婴儿的存活率. 低绿色和高臭氧等综合风险进一步降低了早产婴儿的生存率.

科学领域:

环境健康环境健康
新生儿科学新生儿科学
流行病学流行病学

背景情况:

环境是早产的已知危险因素之一.
需要对影响早产婴儿结果的特定环境暴露进行进一步的研究.

研究的目的:

调查产前暴露于绿色,空气污染和极端温度以及早产婴儿的结果之间的联系.
分析单个和组合的环境指数.

主要方法:

一项使用加拿大国家数据库 (加拿大新生儿网络,加拿大城市环境健康研究联盟) 的队列研究.
包括怀孕22周至28周 (2010-2020年) 之间出生的婴儿在三级新生儿重症监护室 (NICU) 接受治疗.
对环境暴露 (绿色,空气污染物,温度) 在母亲的住所邮政编码的分析,以及它们与婴儿生存率没有重大发病率 (SWMM) 的关联.

主要成果:

总共有14,748名早产婴儿被纳入该研究.
较高的臭氧暴露与SWMM的几率较低有关 (调整后几率比率[AOR],0.83;95% CI,0.74-0.95).
低温与高臭氧或低绿色的联合暴露,以及低绿色与高臭氧的联合暴露,与较低的SWMM (AORs从0.58到0.77) 有显著的关联.

结论:

产前暴露于高水平的臭氧与较差的新生儿结局有关.
包括低温,低绿色和高臭氧在内的环境风险相结合,显著降低了早产婴儿在没有重大疾病的情况下生存的几率.
这些发现强调了怀孕期间环境因素对早产婴儿新生儿健康结果的关键影响.

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