概括
单细胞与白蛋白的比率 (MAR) 显示了与过度活性膀 (OAB) 患病率的U形联系. 马尔可以帮助识别OAB风险,特别是在老年人中.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 炎症标志物的炎症标志物
- 公共卫生 公共卫生
背景情况:
- 过度活跃的膀 (OAB) 是一种常见的疾病,影响生活质量.
- 单细胞与白蛋白比率 (MAR) 是一个新兴的炎症标志物.
- 需要进一步调查MAR和OAB患病率之间的关系.
研究的目的:
- 为了研究单细胞与白蛋白比率 (MAR) 和过活性膀 (OAB) 患病率之间的关联.
- 与其他炎症标志物相比,探索OAB中MAR的诊断价值.
主要方法:
- 利用了34772名成年人的国家健康和营养检查调查 (NHANES) 数据.
- 采用多变量逻辑回归,平滑曲线拟合和子组分析.
- 使用曲线下的面积 (AUC) 评估了MAR的区分能力.
主要成果:
- 在ln(MAR) 和OAB流行率之间发现了显著的U形关联.
- 与传统的炎症标志物相比,MAR对OAB表现出更好的区分能力 (AUC = 0.555).
- 这种联系在老年人和低收入人群中更为明显.
结论:
- 单细胞与白蛋白比率 (MAR) 与OAB具有U形关系.
- 马尔显示出作为评估OAB患病率的生物标志物的潜力.
- 需要进一步的研究来阐明MAR在OAB中的临床实用性.
相关概念视频
Urinary Bladder
3.8K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.8K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
482
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
482
Physiology of the Genitourinary System III: Urine Concentration and Dilution
1.0K
The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...
1.0K
Urodynamic Studies: Uroflowmetry
5.9K
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
5.9K
Anatomy of the Genitourinary System II: Bladder and Urethra
2.1K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
2.1K
Urine Studies I: Urinalysis
1.8K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.8K


