融合性和谱系特异性基因组变化塑造了食糖鸟类的适应性
Ekaterina Osipova1,2,3,4, Meng-Ching Ko5, Konstantin M Petricek6
1Informatics Group, Harvard University, Cambridge, MA, USA.
概括
鸟类通过重复利用遗传元素而进化为高糖饮食. 像MLXIPL这样的基因的融合进化帮助吃糖的鸟类适应新陈代谢糖并保持平衡.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 代谢适应 代谢适应
背景情况:
- 高糖饮食与人类代谢疾病有关.
- 几种鸟类的血统已经融合进化以消费富含糖分的饮食 (花蜜,水果).
研究的目的:
- 研究鸟类糖养适应背后的分子机制.
- 确定使鸟类能够在高糖饮食中壮成长的遗传变化.
主要方法:
- 产生了9个新的鸟类基因组和90个组织特异性转录组.
- 在糖养鸟类谱系中进行了比较的基因组和转录组选.
- 进行了基因功能的实验验证 (例如,赫索金酶3,MLXIPL).
主要成果:
- 在糖养鸟类的蛋白质编码和调节序列中确定了融合选择.
- 观察到与代谢 (脂质,氨基酸,碳水化合物) 和血压相关的基因的序列或表达变化.
- 证明了蜂鸟基酶的功能变化 3.
- 展示了MLXIPL的一个关键代谢调节器的融合进化,在蜂鸟中增加了糖诱导的活动.
结论:
- 融合进化和遗传元素的再利用是鸟类适应高糖饮食的关键机制.
- 在高糖饮食中,MLXIPL通过调节糖和脂质平衡来发挥关键的适应作用.
- 糖养鸟类的遗传适应影响了多种代谢途径.
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