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在一般人群中对浸泡/不浸泡跟踪进行了25年的纵向研究:PAMELA研究

Cesare Cuspidi¹, Rita Facchetti¹, Marijana Tadic²

¹Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.

Journal of hypertension

|February 26, 2026

概括

像浸泡和不浸泡这样的夜间血压 (BP) 模式在25年内无法一致复制. 非浸泡模式特别罕见,只有5.7%的参与者长期观察到.

科学领域:

心脏病学心脏病学
高血压研究高血压研究
时间生物学时间生物学

背景情况:

夜间血压 (BP) 现型,浸泡 (D) 和非浸泡 (ND) 的长期可再生性在人口研究中尚未得到充分证实.
帕梅拉研究前性收集了25年来临床,实验室,门诊血压监测 (ABPM) 和目标器官损伤数据.

研究的目的:

在25年期间调查夜间BP表型 (D和ND) 的长期可重现性.
评估持续性和偶尔性夜间BP表型与目标器官损伤标志物之间的关联.

主要方法:

分析了来自PAMELA研究的541名参与者,并使用了初始调查,10年和25年后续调查的数据.
非浸泡 (ND) 模式定义为与白天值相比,夜间心血压降低<10%.
评估心脏和血管终端器官损伤标志物.

主要成果:

37.15%的参与者在基线时有一个浸泡 (D) 模式,在25年内保持了它 (持久的D).
在25年的随访期间,只有5.7%的参与者表现出持久的非浸泡 (ND) 模式.
在风险因子调整后,在持续/普遍的ND和偶尔的ND/持续的D表型之间没有发现心脏和血管末端器官损伤标志物的显著差异.

结论:

夜间BP表型表现出较差的长期复制性,持久的ND非常罕见.
持续性与偶尔性夜间BP表型和位器官损伤之间的关联需要在更大的队列中进一步调查.

关键词:

这是ABPMABPMABPM的意思.这就是为什么BMI是BMI.这就是为什么B.P.B.B.B.BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA BSA 卡维 (Cavi) 是一个古老的城市.在此之前,我一直在寻找C.V.C.V.D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D 在线观看在线观看在线观看 DBP DBP DBP 的意思是什么意思在IVS中使用IVS.在此期间,LV LV.在 LVH 里面,你会看到 LVH.LVID LVID 在线视频在 LVMI 里面,你会看到 LVMI.左心室过度缩小的情况没有 ND ND ND 没有帕米拉帕米拉在PWW中,它是PWW.动脉压力监测和他们的协会.在RWT中使用RWT.在SBP中使用SBP.这就是为什么SD SD SD.这里是WC,WC,WC.门诊血压监测监测门诊血压监测门诊血压监测血压血压血压血压血压的表型血压的表型身体质量指数 (BMI) 是什么?身体表面积身体表面积身体表面积心脏关节血管指数血管指数这是心血管系统.腹静止血压的血压压力.浸泡浸泡浸泡浸泡浸泡浸泡浸泡浸泡浸泡浸泡一般人口一般人口.腹腔间隔膜的厚度腹腔间隔膜的厚度在左心室的左心室.左心室的内部直径左心室质量指数是左心室质量指数没有浸泡,没有浸泡.没有浸泡,没有浸泡.后壁的厚度后壁的厚度相对墙壁厚度相对墙壁厚度标准偏差的标准偏差压缩性血压压缩性血压是一种血压.损伤目标器官的损伤腰围腰围腰围腰围

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