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接烟雾和SARS-CoV-2:一种危险的组合
Sanna Kjellberg1, Alexander Holm1,2, Susanna L Haga1
1Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
接烟雾暴露会恶化小呼吸道功能,特别是在以前感染了SARS-CoV-2 (COVID-19) 的个人中. 之前的COVID-19结合接烟雾暴露导致更大的肺损伤,影响通风和扩散能力.
科学领域:
- 职业健康 职业健康 职业健康
- 肺部医学 肺部医学
- 传染病流行病学 传染病流行病学
背景情况:
- 接烟雾是众所周知的呼吸系统刺激物.
- 上一篇 SARS-CoV-2 (COVID-19) 感染可能导致持续的肺部问题.
- 接烟雾暴露和之前的COVID-19对肺功能的综合影响尚未得到充分理解.
研究的目的:
- 为了调查是否有COVID-19病史的个人经历了接烟雾暴露的更严重的不良影响.
- 为了比较接烟雾暴露的工人与没有COVID-19病史之间的肺功能参数.
主要方法:
- 横截面研究涉及44名暴露于接烟雾的工人和62名未暴露的个人.
- 进行了包括螺旋计,振荡计,多次呼吸洗 (MBW) 和扩散能力在内的肺功能测试.
- 使用曼-惠特尼,克鲁斯卡尔-瓦利斯测试和多重回归的统计分析.
主要成果:
- 仅仅接烟雾暴露与增加小气道阻力 (R5-20) 有关.
- 暴露与COVID-19病史相结合,显示通风异质性 (MBW) 增加,扩散能力降低.
- 以前患有COVID-19和接烟雾暴露的个体表现出更显著的小呼吸道损伤.
结论:
- 之前的COVID-19感染加剧了接烟雾暴露对小气道功能负面影响.
- 接烟雾暴露和COVID-19病史的结合导致更明显的肺功能障碍.
- 这凸显了在职业肺病风险评估中考虑先前的病毒感染的重要性.
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