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Updated: May 11, 2026

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综合性慢性体内和体外查揭示NFIL3作为T细胞功能障碍的驱动因素

Nayan Jain1, Yuzhe Shi1, Celina May2

  • 1Columbia University Medical Center New York United States.

Cancer discovery
|February 26, 2026
PubMed
概括

NFIL3驱动CAR T细胞的功能障碍,限制它们对固体瘤的有效性. 破坏NFIL3可增强CAR T细胞的持久性和抗瘤活性,为癌症免疫治疗提供了一个新的治疗点.

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相关概念视频

NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...