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Updated: Feb 28, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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一个促进瘤的炎症性SPP1+巨细胞-IL-6-CRP轴驱动膀癌的免疫功能障碍.

Michelle A Tran1, Byuri Angela Cho2, Sudeh Izadmehr3

  • 1Icahn School of Medicine at Mount Sinai New York, New York United States.

Cancer discovery
|February 26, 2026
PubMed
概括

由IL-6和C-反应蛋白 (CRP) 标记的系统性炎症与尿路膀癌 (UC) 中的免疫抑制性瘤巨细胞相关. 准这些巨细胞可能会提高免疫检查点阻断 (ICB) 治疗的有效性.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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