基于视觉变压器模型的剂量预测和光束角度优化,用于BNCT
Yuliang Zong1, Changran Geng2, Gensheng Qian3
1Department of Nuclear Science and Technology, Nanjing University of Aeronautics an d Astronautics, Nanjing University of Aeronautics an d Astronautics, Nanjing, 211106, China.
Physics in medicine and biology
|February 26, 2026
概括
这项研究引入了一种新的深度学习模型,用于中子捕获疗法 (BNCT) 治疗计划. 人工智能准确预测辐射剂量,改善瘤向性和减少器官损伤,以获得更好的患者结果.
科学领域:
- 医学物理 医学物理
- 辐射疗法 辐射疗法
- 人工智能在医学中的应用
背景情况:
- 准确的剂量预测对于有效的中子捕获疗法 (BNCT) 治疗计划至关重要.
- 目前的蒙特卡洛 (MC) 模拟提供了精度,但计算密集,限制了规划效率.
- 开发更快,更准确的剂量预测方法对于优化BNCT计划至关重要.
研究的目的:
- 开发一种先进的神经网络模型,以高效准确地预测BNCT剂量分布.
- 将这个模型与贝叶斯优化进行集成,以选择最佳光束角度.
- 通过改善瘤剂量输送和将风险器官的剂量降至最低来提高治疗规划.
主要方法:
- 一个使用3D视觉转换器 (ViT) 和Mamba模块进行剂量预测的深度学习框架.
- 纳入一个兴趣区域 (ROI) 引导的注意力机制,专注于瘤总体积 (GTV) 和皮肤.
- 将预测剂量集成到贝叶斯光束角度选择的优化策略中.
主要成果:
- 该模型在剂量预测方面取得了高准确性,平均绝对误差 (MAE) 在GTV下低于0.6 Gy,在皮肤下低于0.15 Gy.
- 马传递率超过了90% (2mm/2%) 和97% (3mm/3%),表明与MC模拟的良好一致.
- 治疗优化导致GTV最低剂量平均增加1.8 Gy,而没有增加风险器官 (OAR) 最大剂量.
结论:
- 拟议的深度学习方法为BNCT提供了准确的剂量预测和高效的优化.
- 结果与MC模拟进行验证,证明其临床潜力.
- 这种方法可以促进自动化BNCT治疗规划和优化.
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