低温和寒冷在心律失常发作中的作用:在中国上海市明杭区的个体级别病例交叉研究
Ran Yan1, Siyuan Liu1, Jie Liu1
1Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute), Shanghai, China.
寒冷的天气,包括低温和寒冷时期,显著增加患心律失常的风险. 这一发现强调了考虑环境因素对心血管健康的重要性,特别是在脆弱人群中.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
背景情况:
- 新出现的证据将低温和寒流与各种疾病联系起来.
- 寒冷环境对心律失常发作的具体影响需要进一步研究.
研究的目的:
- 研究低温,感冒和心律失常发作风险之间的关联.
- 量化不同寒冷暴露场景所带来的风险.
主要方法:
- 利用时间分层的病例交叉设计与来自中国上海 (2017-2019) 25957例心律失常病例的门诊病例记录.
- 使用多个温度值和持续时间 (≥2,≥3,≥4天) 定义的寒冷周期.
- 使用分布式滞后非线性模型 (DLNM) 的条件后勤回归来分析高达14天滞后的关联.
主要成果:
- 低环境温度显示,在0-14天内出现心律失常的累积相对风险为1.837 (95% CI: 1.357-2.486).
- 感冒时期的累积相对风险为1.198 (95% CI:1.020-1.407).
- 感冒增加了其他心律不整的风险比心房动/动更多;低温增加了心房动/动的风险更多. 男性和年轻人表现出更高的易感性.
结论:
- 低温和寒冷时期与心律失常发作的风险增加有着明确的联系.
- 这些发现强调了寒冷天气对心血管事件的公共卫生影响.
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