内在能力及其动态变化与心血管疾病风险有关:来自跨国潜在队列的证据
Yanzhi Liu1, Jinxi Wang1, Xuemei Zhao1
1Heart Failure Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Archives of gerontology and geriatrics
|February 26, 2026
概括
保持内在能力 (IC) 对于预防老年人群中心血管疾病 (CVD) 至关重要. 随着时间的推移,更高的IC和IC的改善与降低心血管疾病风险有关.
科学领域:
- 老年学是指老年学的学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是老年人死亡和残疾的主要原因.
- 内在能力 (IC) 是健康结果的新兴指标,但纵向数据有限.
- 本研究研究了基线IC及其在三大前性队列中与心血管疾病相关的变化.
研究的目的:
- 调查基线内在容量 (IC) 和IC的纵向变化与发生心血管疾病 (CVD) 的风险之间的关联.
- 在中国,美国和英国的不同人口中分析这些关联.
主要方法:
- 利用了来自中国健康与退休纵向研究 (CHARLS),健康与退休研究 (HRS) 和英国老化纵向研究 (ELSA) 的数据.
- 计算IC作为运动,认知,心理健康,感官功能和活力的复合得分.
- 通过三角过渡和纵向轨迹评估IC变化;使用Cox比例危险模型记录和分析事故心血管疾病事件.
主要成果:
- 在所有三个队列中,更高的基线内在容量 (IC) 始终与心血管疾病 (CVD) 的风险降低有关.
- 在基线IC较低的个体中,改善至IC的较高三位数显著降低了心血管疾病风险.
- 与稳定的高IC轨迹相比,其他轨迹,包括下降的IC,与心血管疾病风险增加有关.
结论:
- 基线内在容量 (IC) 和其纵向变化都是长期心血管疾病 (CVD) 风险的显著预测因素.
- 保持较高的IC和经历良好的IC变化表明对心血管疾病有保护作用.
- 较低的IC,下降的IC三位数和不良的IC轨迹与老年人群中心血管疾病风险增加有关.
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