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角膜穿孔和变薄的潜在病因是否会影响粘合剂应用后的结果?

Ryan S Huang¹, Manokamna Agarwal², Michael Mimouni³

¹Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

|February 26, 2026

概括

对于角膜穿孔的烯酸组织粘合剂 (CTA) 结果因原因而异. 创伤病例显示出更好的结果,而神经变病例的重复粘合和穿透角质形成 (PK) 率更高.

科学领域:

眼科医生眼科眼科
角膜外科手术角膜外科手术
组织粘合剂组织粘合剂

背景情况:

角膜穿孔和稀薄会对视力产生重大威胁.
烯酸组织粘合剂 (CTA) 是一个常见的管理选项.
病因学可能会影响CTA治疗结果.

研究的目的:

评估CTA在控制角膜穿孔和稀薄方面的有效性.
根据角膜病理的潜在原因分析结果.
为了比较需要重复的CTA应用和进展到透性角质形成 (PK) 在不同的病因.

主要方法:

对174只用CTA治疗的眼睛进行了回顾性队列研究.
病例分为传染性,免疫介导,眼睛表面疾病,神经变性或与创伤相关的病因.
主要结果:重复CTA应用和进展到PK. 进行了卡普兰-梅尔和多变量逻辑回归分析.

主要成果:

神经损伤病例需要最多重复的CTA应用 (2.0 ± 0.8),并且进展到PK的比例最高 (43.5%).
创伤病例显示了最有利的无PK生存率和较低的重复CTA和PK的几率.
多变量分析显示,创伤与重复CTA和PK的几率较低有关,而神经营养病因增加了PK的几率.

结论:

对于角膜穿孔和稀释的CTA结果受到潜在病因的显著影响.
特定于病因的预后对于识别高风险患者至关重要.
根据病因学量身定制的管理策略可以优化结果,并可能减少穿透角质形成术的需要.

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