口腔致病细菌如何可能导致自身免疫性肝病的炎症过程? 来自系统审查的结果
Esperouz Fariba1, Villani Rosanna2, Ciavarella Domenico1
1Department of Clinical and Experimental Medicine, School of Dentistry, University of Foggia, 71121 Foggia.
Clinics and research in hepatology and gastroenterology
|February 26, 2026
概括
口腔微生物群失调与自身免疫性肝脏疾病 (AILD) 有关. 特定的细菌变化和炎症表明,口腔肠肝轴可能为AIH和PBC等疾病提供新的诊断和治疗点.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 口腔肠肝轴与自身免疫性肝病 (AILD) 有关,包括自身免疫性肝炎 (AIH) 和原发性胆道胆炎 (PBC).
- 口腔微生物的变化可能会影响肝脏免疫力,但这种联系需要进一步阐明.
研究的目的:
- 系统地审查将口腔微生物群失生症与AILDs联系在一起的证据.
- 分析AILD患者的微生物转移,炎症标志物和诊断潜力.
主要方法:
- 在PubMed,Web of Science和Scopus的系统文献搜索到2026年1月.
- 包括比较AILD患者口腔微生物群与健康对照组的研究.
- 使用纽卡斯尔-太华尺度 (NOS) 进行质量评估.
主要成果:
- 六项研究 (2015-2021年) 涉及252名AILD患者和345名对照,发现了显著的口腔功能失调.
- 在AILD中,特别是PBC中,发现了Veillonella和Eubacterium的增加,以及Streptococcus和Fusobacterium的减少.
- 微生物变化与升高的唾液炎症标志物和疾病活性相关,表明口腔-肠-肝轴相互作用.
结论:
- 证据支持口腔微生物群失生症和AILDs的炎症之间的联系.
- 虽然因果关系尚未被证明,但口腔-肠-肝脏轴呈现出潜在的生物标志物和治疗途径.
- 需要进一步的研究来探索这些关联及其临床影响.
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