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Updated: Feb 28, 2026

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
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Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Published on: February 28, 2016

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通过RNautophagy对α-synuclein/SNCA mRNA的降解进行了RNautophagy

Chihana Kabuta1, Fumihiko Hakuno2, Naoyuki Kataoka2

  • 1Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Neurochemistry international
|February 26, 2026
PubMed
概括

通过SIDT2介导的RNautophagy通过其5'未翻译区域的氨酸丰富区域降解α-synucleinmRNA. 这一途径影响α-synuclein mRNA的循环,并可能提供关于Lewy体疾病的见解.

关键词:
自自是一种自的过程.痴呆症与利维体的痴呆症.这是一个富含关的地区.Lysosomes 是一个溶解体.神经退行性疾病是一种神经退行性疾病.帕金森病是帕金森氏症的一种疾病.

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