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Updated: Feb 28, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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准PCK1以克服CDK4/6抑制剂的耐药性,用于乳腺癌治疗

Chen-Shiou Wu1, Hsiao-Fan Chen2, Kieu-Thanh Huynh3

  • 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.

Cancer letters
|February 26, 2026
PubMed
概括

基酸碳素激酶1 (PCK1) 促进乳腺癌的生长和对CDK4/6抑制剂的抵抗. 向PCK1使用everolimus或auranofin与CDK4/6抑制剂协同作用,提供了新的乳腺癌治疗策略.

关键词:
这是一种CDK4/6抑制剂.环 D3 环 D3 环 D3 环 D3在PCK1中使用PCK1.乳腺癌 乳腺癌 乳腺癌药物耐药性 耐药性 药物耐药性

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