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相关概念视频

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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用于采用细胞转移疗法的热声遗传学.

Ana Baez1, Kyle Hazel1, Zakary Guertin1

  • 1Department of Biology, Concordia University, Montreal H4B 1R6, Canada.

Journal of controlled release : official journal of the Controlled Release Society
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概括

聚焦超声波 (FUS) 能够精确控制用于癌症治疗的工程免疫细胞. 热声遗传学使用FUS远程激活细胞,提高采用细胞转移 (ACT) 的安全性和有效性.

关键词:
声学 声学 在声学方面在CAR-T细胞中.聚焦式超声波的使用方法高强度的聚焦超声波高强度的聚焦超声波免疫治疗是一种免疫疗法.有针对性的治疗.

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科学领域:

  • 免疫治疗是一种免疫疗法.
  • 生物技术是生物技术.
  • 在瘤学瘤学.

背景情况:

  • 采用细胞转移 (ACT) 在癌症治疗中表现有前途,但面临毒性和瘤微环境抑制等挑战.
  • 目前用于ACT的诱导基因电路系统在临床转化方面存在局限性,原因是药理动力学和组织透.
  • 聚焦超声波 (FUS) 为局部深层组织激活提供了一种非侵入性方法.

研究的目的:

  • 审查基于ACT的免疫疗法的FUS介导的热诱导基因控制方面的进展.
  • 讨论当前ACT平台的局限性以及可控制系统的需求.
  • 探索热声遗传学在精确和可逆控制工程免疫细胞方面的潜力.

主要方法:

  • 审查当前的ACT平台 (TIL,TCR-T,CAR-T) 和它们的局限性.
  • 讨论热冲击促进剂 (HSP70) 作为热基因开关.
  • 使用FUS在各种细胞类型中诱导基因表达的临床前研究摘要.

主要成果:

  • FUS可以进行局部和深层组织加热,以精确激活基因工程细胞.
  • 热诱导促进剂,特别是HSP70元素,是热基因开关的关键组成部分.
  • 临床前研究表明FUS介导诱导基因表达的可行性.

结论:

  • 热声遗传学为远程,精确和可逆控制工程免疫细胞提供了一个有希望的策略.
  • 这种方法有可能提高基于ACT的免疫疗法的安全性和有效性.
  • 需要进一步的研究来解决局限性和推进临床翻译.