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Updated: Feb 28, 2026

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代代谢物D-2-基酸盐调节IDH1-突变性质瘤中actin动力学和核平衡

Kirti Lathoria1, Sonia B Umdor1, Shruti Patrick1

  • 1Division of Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar 122052, India.

Cellular signalling
|February 26, 2026
PubMed
概括

在IDH突变性质瘤中,代代谢D-2-基酸盐 (D-2-HG) 破坏了actin动态,影响了核组织和DNA损伤. 恢复actin聚合可以逆转这些有害影响.

关键词:
细胞骨架 细胞骨架这是一种D-2-基酸盐.质瘤是一种质瘤.一个IDH1突变.拉米兰 (Lamin) 拉米兰 (Lamin) 是一个

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