相关实验视频

Updated: Feb 28, 2026

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

测试胰岛素类生长因子信使RNA结合蛋白3作为替代性免疫组织化学标记物,用于在细胞学和手术样本中THADA融合的不确定的甲状腺结节

Di Ai¹, Youjie Zhang², Kartik Viswanathan³

¹Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Cancer cytopathology

|February 26, 2026

概括

胰岛素类生长因子信使RNA结合蛋白3 (IMP3) 显示为甲状腺结节与THADA基因融合的标记物具有前途. 这一发现有助于诊断不确定的甲状腺结节,并检测入侵.

科学领域:

内分泌学在内分泌学.
分子病理学分子病理学
在瘤学瘤学.

背景情况:

甲状腺腺瘤相关 (THADA) 基因融合驱动胰岛素样生长因子信使RNA结合蛋白3 (IMP3) 在甲状腺结节中的过度表达.
已知IMP3在甲状腺瘤中的作用,但其在THADA融合阳性病例中的实用性尚未评估.

研究的目的:

评估IMP3表达作为THADA融合阳性甲状腺结节的潜在生物标志物.
在细胞学和手术样本中评估IMP3的实用性.

主要方法:

在20个不确定的甲状腺结核中通过免疫组织化学评估IMP3表达 (11个THADA融合阳性,9个对照).
分析了细胞学和手术样本,使用血素和素和IMP3/NRAS Q61R免疫染.
评分IMP3染色强度和程度;综合评分>2被认为是积极的.

主要成果:

所有的THADA聚变阳性结节都在病变细胞中表现出强烈的,扩散的细胞质IMP3染色.
邻近的正常甲状腺组织和所有对照病例均为IMP3阴性.
在所有评估的病例中,NRAS Q61R免疫染是负的.

结论:

IMP3 作为一个有前途的替代标记物,用于含有 THADA 融合的不确定的甲状腺结节.
IMP3染色在细胞学和手术样本中都是有效的.
IMP3可能有助于识别微妙的囊或血管入侵.

关键词:

达达核聚变 (THADA) 技术的发展甲状腺Seqq 甲状腺细胞科学细胞学免疫组织化学免疫组织化学胰岛素类生长因子信使RNA结合蛋白3 (IMP3)甲状腺结节甲状腺结节

更多相关视频

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...