在COPD中对纵向CT纤维化特征的持续同质分析
Yusuke Shiraishi1, Naoya Tanabe1, Shizuo Kaji2
1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
The European respiratory journal
|February 26, 2026
概括
持久性同源性 (PH) 在慢性阻塞性肺病 (COPD) 患者的CT扫描上量化肺纤维化. 较高的PH纤维化百分比预测恶化和死亡率,作为预后成像标志物.
科学领域:
- 医学成像分析分析 医学成像分析
- 拓学数据分析的分析.
- 肺部医学 肺部医学
背景情况:
- 纤维化和肺往往在慢性阻塞性肺病 (COPD) 中并存,这对计算机断层扫描 (CT) 量化提出了挑战.
- 持久同质 (PH) 是一种拓数据分析方法,它提供了一种从灰度图像中提取结构特征的方法.
- 这项研究利用PH量化COPD患者中肺缩和非肺缩的纤维化病变.
研究的目的:
- 在CT扫描上使用PH量化COPD肺部纤维化病变.
- 调查基于PH的COPD纤维化量化的临床影响.
- 评估PH衍生的纤维化测量和COPD结果之间的关联.
主要方法:
- 从肺癌查 (LCS) 队列和两个COPD队列 (京都大学[KU]和京都-Himeji) 招募了受试者.
- 基于CT值模式和空间拓学,使用持久性同质 (PH) 来将voxel分类为纤维化或非纤维化.
- 计算了纤维化肺体积 (PH-纤维化%) 的百分比,并与间歇性肺异常 (ILA) 和COPD结局相关联.
主要成果:
- 较高的PH纤维化%与LCS和KU队列中的ILA相关.
- 基线PH纤维化%的增加在两个COPD队列中独立地与更高的未来恶化风险相关 (KU HR: 1.39;京都-Himeji HR: 3.35).
- 较高的PH纤维化%与KU队列的死亡率增加有关 (HR: 1.94) 并显示在京都-希梅吉队列 (HR: 1.86) 中出现了类似的趋势. 长度增加的PH纤维化%与恶化和死亡率有关.
结论:
- 持久性同质性 (PH) 在CT扫描上有效量化纤维化病变.
- PH-纤维化%显示为COPD患者的预后成像生物标志物有前途.
- 这种技术可以帮助评估疾病的严重程度和预测COPD的结果.
相关概念视频
01:20COPD: Pathogenesis and Clinical Features
2.0K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.2K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.2K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.9K
01:24Chronic Obstructive Pulmonary Disease
2.8K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.8K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.0K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.9K