婴儿期的T细胞种群在母体益生菌补充剂后,以预防无氧皮肤炎
Dinastry Pramadita Zakiudin1,2, Anne Dorthea Bjerkenes Rø3,4, Vibeke Videm3,4
1Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Clinical and translational allergy
|February 26, 2026
概括
母亲补充益生菌并没有改变10天或2岁婴儿的T细胞种群. 这表明,亚托皮性皮肤炎的减少可能与这些特定的免疫细胞变化无关.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
- 儿科过敏症儿童过敏症
背景情况:
- 孕妇在怀孕和母乳养期间摄入益生菌,此前曾显示后代的亚托皮炎 (AD) 减少.
- 一项先前的分析表明,这种保护作用可能与3个月大时T辅助细胞22 (Th22) 细胞百分比下降有关.
研究的目的:
- 研究母性益生菌对后代各种T辅助 (Th) 细胞子集和调节性T细胞 (Treg) 的纵向影响.
- 为了比较10天,3个月和2岁的免疫细胞概况.
主要方法:
- 一项随机对照试验涉及415名孕妇,她们被分配给益生菌或安慰剂牛奶.
- 后代的血液样本通过10天 (n=112) 和2年 (n=156) 的流细胞计分析了Treg和Th子集 (Th1,Th2,Th17,Th22).
- 从3个月大的婴儿 (n=76) 的数据被纳入用于使用线性混合模型进行纵向比较.
主要成果:
- 在10天和2岁时,在益生菌和安慰剂组之间没有观察到T细胞群 (Th1,Th2,Th17,Th22,Treg) 的显著差异.
- 在3个月后的Th22百分比中,之前注意到的降低在以后的时间点中没有持续.
结论:
- 在母亲服用益生菌3个月后观察到的Th22细胞的减少可能不是预防亚托皮炎的主要机制.
- 由于T细胞形状没有持续的差异,这表明其他因素可能会调解益生菌对儿童过敏的保护作用.
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