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Updated: Feb 28, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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用小分子稳定剂rezatapoptopt针对p53癌症突变Y220C,Y220N和Y220S进行向

Danai Mavridi1,2, Julianne S Funk3, Dimitrios-Ilias Balourdas1,2

  • 1Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.

Cell death & disease
|February 26, 2026
PubMed
概括

雷扎塔普托普特药物在重新激活p53癌症突变Y220C和Y220S方面表现有前途,恢复蛋白质稳定性和抗癌作用. 然而,对Y220N突变的疗效仍然有限,这给开发泛突变疗法带来了挑战.

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