相关实验视频

Updated: Feb 28, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

TBC1域家族成员23对于STING介导的抗黑色素瘤作用至关重要

Shenghui Niu¹, Guangmei Li², Pengcheng Wei¹

¹Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, China.

Molecular biomedicine

|February 26, 2026

概括

TBC1D23对于干扰素基因 (cGAS-STING) 循环GMP-AMP合成酶刺激通路至关重要,通过促进T细胞反应来增强抗瘤免疫力. 它的缺乏加速黑色素瘤的进展,突出其在癌症免疫力中的作用.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
癌症研究癌症研究

背景情况:

干扰素基因 (cGAS-STING) 的循环GMP-AMP合成酶刺激通路对于对瘤的先天免疫反应至关重要.
膀运输调节了通过亚细胞区的cGAS-STING通路的激活.
TBC1域家族成员23 (TBC1D23) 调节囊泡运输,并参与STING信号传递.

研究的目的:

研究TBC1D23在抗瘤免疫中的生理作用.
确定TBC1D23对cGAS-STING通路和黑色素瘤进展的影响.

主要方法:

对黑色素瘤TBC1D23表达的分析及其与免疫透和预后的相关性.
在TBC1D23缺陷模型中评估STING-依赖的化学激素表达和免疫细胞功能.
在没有TBC1D的情况下评估黑色素瘤进展23.

主要成果:

高TBC1D23表达与增强的免疫透和黑色素瘤更好的预后相关.
缺少TBC1D23会损害STING介导的化学激素的产生,巨细胞的成熟和CD8+ T细胞的反应.
失去TBC1D23会加速黑色素瘤的进展.

结论:

TBC1D23是抗瘤免疫中STING信号的重要调节者.
TBC1D23在调解对黑色素瘤的免疫反应方面发挥着至关重要的作用.
TBC1D23代表了增强癌症免疫疗法的潜在治疗标.

关键词:

反瘤免疫力抗瘤免疫力 CD8+ T细胞透 CD8+ T细胞透黑色素瘤是一种黑色素瘤.干扰素基因刺激器 (STING) 信号传递 TBC1 域名家族成员23 (TBC1D23)

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

相关概念视频

The Intrinsic Apoptotic Pathway

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...

Receptor Downregulation in MVBs

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...