在新生儿,婴儿和早期青少年中,前骨架构的功能性变化
Jiaojian Wang1,2, Qinmu Peng1,2, Minhui Ouyang1,2
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Scientific reports
|February 26, 2026
概括
这项研究揭示了大脑的前 (PCun) 区域如何从婴儿期到青春期发展连接. 它还显示了PCun在自闭症谱系障碍 (ASD) 中的结构性改变.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 前 (PCun) 对于空间,视觉运动和社会认知至关重要.
- 它从出生到青春期的功能连接发展在很大程度上是未知的.
- 了解PCun发育对于研究大脑疾病至关重要.
研究的目的:
- 为了研究脑发育 (出生到青春期) 期间PCun亚区域的功能连接性变化.
- 检查自闭症谱系障碍 (ASD) 中的PCun亚区域变化.
主要方法:
- 使用了多模体横截面扩散MRI和静止状态fMRI.
- 受试者从新生儿到早期青少年,包括患有自闭症的人.
- 使用基于连接性的分片统一确定了PCun分区.
主要成果:
- 在PCun亚区域与默认模式网络 (DMN) 和小脑的功能连接方面观察到显著的发育变化.
- 在ASD和典型的发展个体中,PCun分片化模式类似.
- 在ASD受试者中发现,背后PCun亚区域体积显著下降.
结论:
- 本研究阐明了PCun子区域及其相关网络的功能发展轨迹.
- 它强调了ASD中特定的PCun亚区域变化,提供了对该疾病神经生物学的见解.
- 这些发现有助于理解在发育过程中和ASD中先骨的不断变化的结构.
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