基于真的生物仿真贴片用于动态心脏修复:辅助结构和翻译挑战
Rishatani Gunasegaran1,2, Rania Hussien Al-Ashwal3,4, Norhana Jusoh1,5
1Department of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Technologi Malaysia, 81310, Johor Bahru, Johor, Malaysia.
Cardiovascular engineering and technology
|February 26, 2026
概括
本综述探讨了用于更好的心脏贴片粘附的粘膜生物粘合剂和辅助性设计. 这些创新旨在在湿心环境中实现持久的,符合组织的心肌修复.
科学领域:
- 生物材料科学 生物材料科学
- 心血管工程 心血管工程
- 再生医学是一种再生医学.
背景情况:
- 脊心贴片对于心肌修复至关重要.
- 目前的贴片在充满活力的心脏环境中面临着粘附和整合的挑战.
- 提高补丁性能需要新的生物材料和结构设计.
研究的目的:
- 审查增强表心贴片粘附和整合的战略.
- 找出有前途的解决方案,如基于粘素的生物粘合剂和辅助性设计.
- 为了解决当前心肌修复技术的局限性.
主要方法:
- 对大约150篇同行评审文章 (2010-2024) 的范围审查.
- 在PubMed,Scopus和科学网上进行文献搜索.
- 对粘合生物材料,贴片设计和修复方法的研究进行主题综合.
主要成果:
- 商用贴片在潮湿,动态条件下缺乏粘附性.
- 氨酸在湿粘和生物相容性方面表现有前途,但面临翻译障碍.
- 辅助设计提高了补丁的灵活性和符合性,尽管制造和可扩展性仍然是挑战.
结论:
- 将粘膜生物粘合剂与辅助性设计相结合,为先进的心脏贴片提供了一条道路.
- 需要进一步的研究来解决临床翻译的制造,可重复性和免疫安全问题.
相关概念视频
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...


