可视化恶性进展:基于现场CD109的空间免疫光试验,在瘤微环境内划分了乳头状腺癌到形甲状腺癌的转变
Tomoko Cohen1,2, Keiji Suzuki3, Katsuya Matsuda1,4
1Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Scientific reports
|February 26, 2026
概括
无塑性甲状腺癌 (ATC) 由乳头甲状腺癌 (PTC) 产生的,通过瘤微环境 (TME) 促进与癌症相关的纤维细胞和巨细胞的透,驱动积极的转变.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 无塑性甲状腺癌 (ATC) 是一种罕见的,激进的甲状腺癌亚型.
- 从差异化甲状腺癌驱动ATC发展的分子机制仍然不清楚.
研究的目的:
- 为了研究分子过程和瘤微环境 (TME) 涉及到乳头甲状腺癌 (PTC) 转化为ATC.
主要方法:
- 利用一种新的空间免疫光 (SPI) 试验来分析在同时存在的ATC和PTC病例中的标记物表达.
- 检查了CD109,CK8/18,E-cadherin,vimentin,PCNA,αSMA,Iba-1,collagen (COL) III/VI,TGFBI,YAP,periostin和S100的差异性表达,这些蛋白质的含量是什么?
主要成果:
- 观察到PTC和ATC标记在它们的接口之间有明显的表达模式和相互过渡.
- 确定了一种ATC特定的TME,其特征是增加Iba-1和S100阳性巨细胞和独特的ATC癌症相关纤维细胞 (CAF).
- ATC-CAF与细胞外矩阵硬化,亡诱导和S100释放有关,促进表皮细胞-介质细胞过渡和亚塑性转变.
结论:
- 无塑性转化是由专门的ATC-TME驱动的,而不仅仅是克隆扩张.
- ATC-TME涉及CAF和巨细胞之间的相互作用,导致细胞外基质重塑和细胞变化,促进恶性进展.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...