与动态多组分运动相比,OsteoStrong对老年女性骨强度的影响:BONEMORE非劣势随机对照试验
Peter W S Lindberg1, Kristin Moystad Michelet2, Christina Kaijser Alin2
1Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, 171 77, Sweden. peter.lindberg@ki.se.
发现OsteoStrong® (OS) 在改善老年女性骨材料强度指数 (BMSi) 方面与动态多元组件运动 (DME) 不逊色. 然而,在本研究中,DME的有效性有限,这会影响这些骨健康发现的解释.
科学领域:
- 老年学是指老年学的学科.
- 整形外科 整形外科 整形外科
- 运动科学 运动科学
背景情况:
- 老年妇女的骨健康是一个重大问题,骨质疏松症影响了这一人口群的很大一部分.
- 动态多元组件运动 (DME) 是改善骨健康的常见干预措施,但其有效性可能有所不同.
- OsteoStrong® (OS) 是一种新的干预措施,声称可以改善骨强度,但与已建立的炼计划相比,其有效性尚未得到充分证实.
研究的目的:
- 为了比较OsteoStrong® (OS) 与动态多组分运动 (DME) 在65-79岁女性的骨质强度指数 (BMSi) 的疗效.
- 为了确定OS是否在改善骨强度的关键指标BMSi方面不低于DME.
- 评估二次结果,包括骨矿物质密度 (BMD) 和骨周转指标.
主要方法:
- 一项随机对照试验,涉及194名患有骨质疏松症或骨质疏松症的女性 (65-79岁).
- 参与者被随机分配到9个月的每周一次的OS (20分钟) 或每周两次的DME (60分钟/会话).
- 主要结局是BMSi通过冲击微印痕测量;次要结局包括BMD和骨标记物.
主要成果:
- 在OS和DME组之间没有观察到BMSi或9个月的其他测量结果的显著差异.
- 与DME相比,OsteoStrong®达到预先规定的非劣势差额 (平均差异为1.16,CI -1.51至3.82).
- 在OS组观察到BMSi的显著增加 (2.9%),在DME组观察到腰椎骨髓 BMD的显著增加 (0.8%).
结论:
- 在老年妇女中,OsteoStrong®在改善骨材强度指数方面表现出与动态多元组件运动相比的非劣势.
- 该研究发现,对于大多数结局,干预措施之间没有显著差异,这表明在试验的局限性范围内,干预措施的效果相似.
- 由于观察到DME干预对BMSi的缺乏有效性,因此对研究结果的解释受到限制.
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