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相关概念视频

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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相关实验视频

Updated: Feb 28, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
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基于转录基因组的气效应评估,以防止UVA诱导的光衰老,使用人造皮肤模型.

Takeshi Kiyoi1, Shuang Liu2, Kentaro Uchida3

  • 1Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.

Geriatrics & gerontology international
|February 26, 2026
PubMed
概括

气可以通过减少氧化应激和细胞衰老来预防紫外线辐射引起的皮肤衰老. 这项研究使用人造皮肤来展示对抗紫外线损伤的潜在保护作用.

关键词:
紫外线引起的光衰老是UVA引起的.人造皮肤的人造皮肤.分子分子的分子.转录组分析 转录组分析

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科学领域:

  • 皮肤病学和光生物学的研究.
  • 在体外皮肤模型和转录学.

背景情况:

  • 紫外线A (UVA) 辐射会通过氧化应激引起皮肤的光衰老.
  • 气 (H2) 显示出防止光衰老的潜力,但机制尚不清楚.
  • 在体外模型为研究光衰老提供了动物试验的替代方案.

研究的目的:

  • 评估气对紫外线引起的光衰老的预防作用.
  • 研究的保护作用背后的分子机制.
  • 用人造皮肤模型进行短期体外研究.

主要方法:

  • 人造皮肤被暴露在UVA辐射 (7或10.5 J/cm2/day) 中,持续3个周期.
  • 在照射期之间发生了含有或不含有1.3%气的化.
  • 进行了转录和组织学分析,以评估细胞变化.

主要成果:

  • 低剂量紫外线 (7 J/cm2/day) 诱导了与光衰老相关的显著转录基因变化.
  • 高剂量的UVA (10.5 J/cm2/day) 导致更严重的组织学损伤,但转录组变化较少.
  • 气调节UVA诱导的NRF2和NFκB1通路,并抑制了p53介导的衰老.

结论:

  • 与光衰老相关的转录基因变化可以在人造皮肤中检测到,即使组织学损伤最小.
  • 气可能会防止紫外线诱导的细胞应激和衰老.
  • 这项研究支持对分子的进一步研究,以防止UVA诱导的光衰老.