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肝动脉输液化疗 (HAIC) 与高级肝细胞癌的顺序或并发性全身向免疫疗法相结合:单中心回顾性研究

Zheng Li¹, Miaogang Xiong¹, Yang Xiang¹

¹National Key Clinical Specialty - General Surgery, Hepatobiliary Surgery, Academician (Expert) Workstation, Sichuan Digestive System Disease Clinical Medical Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, P. R. China.

World journal of surgical oncology

|February 26, 2026

概括

同时服用HAIC,ICI和TKI显著改善了晚期肝癌患者的生存率. 这种三重治疗策略与连续治疗相比,提供了更好的整体和无进展生存率.

科学领域:

肝胆瘤学肝胆瘤学
医学瘤学医学瘤学
临床药理学临床药理学

背景情况:

晚期肝细胞癌 (HCC) 是一个重大的临床挑战.
结合肝动脉输液化疗 (HAIC),免疫检查点抑制剂 (ICI) 和氨酸激酶抑制剂 (TKI) 的三重疗法显示出有前途.
对于巴塞罗那诊所肝癌 (BCLC) 阶段C HCC,这些药物的最佳测序仍未确定.

研究的目的:

为了比较基于HAIC的并发与连续HAIC三重疗法的疗效和安全性,在先进的HCC.
评估整体生存率 (OS),无进展生存率 (PFS) 和客观反应率 (ORR).

主要方法:

对235名BCLC阶段C HCC患者的回顾性分析,这些患者接受了基于FOLFOX的HAIC与ICI和TKI.
根据治疗时间,患者被分为顺序 (SE) 和并发 (Con) 组.
倾向性得分匹配 (PSM) 用于平衡基线特征,结果为每组85名患者.

主要成果:

与顺序治疗相比,同时治疗的中位寿命显著更长 (14.5 vs 11.2 个月,P<0.01) 和PFS (7.9 vs 6.2 个月).
同时组的客观响应率 (ORR) 在并发组中更高.
同时治疗组的高 bilirubinemia 和贫血率较高,但没有报告5级不良事件.

结论:

同时基于HAIC的三重疗法 (ICI和TKI) 显示,与顺序管理相比,先进的HCC患者的生存结果优越.
虽然与特定不良事件的增加有关,同时治疗为BCLCCC阶段C HCC提供了更有效的治疗策略.

关键词:

肝动脉输液化疗肝动脉输液化疗肝细胞癌是肝细胞癌.免疫治疗是一种免疫疗法.顺序和同时进行.有针对性的治疗.

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