在炎症性肠病期间,肠道的跨王国微生物相互作用
Liwei Li1, Fuqing Cai1, Zheng Liu1
1The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Journal of translational medicine
|February 26, 2026
概括
炎症性肠病 (IBD) 涉及肠道微生物组的破坏. 了解这些多领域相互作用是开发IBD管理个性化疗法的关键.
科学领域:
- 胃肠道学和微生物学
- 研究了肠道微生物组在炎症性肠道疾病 (IBD) 发病过程中的复杂相互作用.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),以慢性胃肠道炎症为标志.
- 肠道微生物组失调越来越被认为是IBD的一个关键因素,涉及细菌,真菌,原生动物和病毒之间的相互作用.
研究的目的:
- 审查当前关于微生物群落及其代谢物在IBD发展和进展中的作用的文献.
- 评估细菌-真菌,细菌-原生菌和菌-细菌相互作用对免疫路径和治疗策略的影响.
主要方法:
- 对人类和临床前研究进行了全面的叙事文献综述.
- 搜索生物医学数据库,研究IBD中的微生物群落,代谢物,真菌,原生动物和病毒.
- 分析了专注于微生物相互作用及其对免疫系统功能和疾病进展的影响的研究.
主要成果:
- 不同的微生物王国相互作用,影响代谢物生产和免疫功能,这在IBD中至关重要.
- 微生物代谢物如SCFA,醇和胆酸调节粘膜免疫力;干扰有助于慢性炎症.
- 多领域疗法 (益生菌,FMT) 是有前途的,但由于临床变异性而面临挑战.
结论:
- 将IBD视为微生物生态系统的破坏,有助于开发个性化的治疗方法.
- 针对特定微生物相互作用的多主题和基于微生物组的干预措施为个性化IBD疗法提供了潜力.
- 需要进一步的研究和临床试验来将这些发现转化为临床实践.
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