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一种上升的大动脉壁血栓的病例,使性结肠炎复杂化
Yu Takahashi1, Yusuke Inaba2, Sachito Minegishi2
1Department of Cardiovascular Surgery, Kyorin University, 6-20-2 Shinkawa, Mitaka-shi, Mitaka-shi, Tokyo, 181-8611, Japan. yutakahashi0926@gmail.com.
Journal of cardiothoracic surgery
|February 26, 2026
概括
一个患有性结肠炎的患者罕见的上升性大动脉血栓形成病例,通过手术和免疫调节成功治疗. 这突出了潜在的,虽然不常见的,炎症性肠病的肠外表现.
科学领域:
- 心血管医学 心血管医学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 肠外表现 (EIMs) 的UC是常见的,但大动脉血栓是极其罕见的.
- 上升的大动脉壁血栓构成灾难性栓塞事件的重大风险.
研究的目的:
- 在患有性结肠炎的患者中报告一种罕见的上升性大动脉血栓的病例.
- 讨论诊断和治疗方面的挑战.
- 审查与UC相关的大动脉血栓形成的文献.
主要方法:
- 一名60岁的男性患者患有UC呈现出水性腹和血.
- 与对比度增强的计算机断层扫描揭示了上升的大动脉壁血栓.
- 该患者接受了皮质类固醇,单克隆抗体 (向介素-12/23 p40亚单元) 和手术大动脉置换治疗.
- 组织病理学检查证实非动脉瘤大动脉壁血栓.
主要成果:
- 皮质类固醇的症状改善,随后成功进行了对大动脉血栓的手术干预.
- 患者耐受了使用单克隆抗体的术后免疫调节,允许皮质类固醇逐渐减少.
- 组织病理学显示轻度动脉样硬化和内部弹性层间断,没有显著的动脉瘤变化.
结论:
- 上升性大动脉血栓是性结肠炎的极其罕见但可能危及生命的肠外表现.
- 涉及胃肠病学,心脏病学,手术和免疫学的多学科管理至关重要.
- 早期诊断和干预,包括手术修复和优化免疫调节,是有利结果的关键.
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