在查CT检测到的偶然心血管化:对长期随访的预后影响
1Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
在低剂量胸部CT上偶然发生的胸前动脉化 (TAC) 预测死亡率,而冠状动脉化 (CAC) 预测主要的不良心血管事件 (MACE). 将这些结结合起来并没有提高预后准确度,仅超出单独的CAC.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 预防医学 预防医学
背景情况:
- 在低剂量胸部CT (LDCT) 上偶发心血管化的预后意义尚不清楚.
- 结石化包括冠状动脉结石化 (CAC),胸前大动脉结石化 (TAC),大动脉结石化 (AVC) 和心肌环状结石化 (MAC).
研究的目的:
- 评估在查LDCT中检测到的偶然心血管化的长期预后意义.
- 评估与所有原因死亡率 (ACM) 和主要心血管不良事件 (MACE) 的关联.
主要方法:
- 对2434名接受LDCT的个人进行了回顾性队列研究.
- 使用专门的软件量化CAC,TAC,AVC和MAC.
- 多变量考克斯回归和C指数用于预后评估.
主要成果:
- 偶然的TAC (最高类别) 与ACM强烈相关 (HR=3.11).
- 偶然的CAC (最高类别) 与MACE强烈相关 (HR=8.67).
- 组合模型并没有显著改善 ACM 或 MACE 的预后值,仅超出单独的 CAC.
结论:
- 偶然的TAC预测长期增加了所有原因的死亡风险.
- 偶然的CAC预测了主要的不良心血管事件.
- 对这些化的综合评估,与单独的CAC相比,没有显著的增量预后益处.
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