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Updated: Feb 28, 2026

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破坏STIL-BRCA1轴会导致中枢细胞体放大和基因组不稳定

Srishti Sanghi1, Mahima Joshi1, Priyanka Singh1

  • 1Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India.

FEBS letters
|February 27, 2026
PubMed
概括

一种与癌症相关的STIL突变 (S76L) 破坏了BRCA1相互作用,导致中枢细胞体放大和DNA损伤. 这种STIL-BRCA1轴的破坏促进了基因组的不稳定性,这是癌症发展和进展的关键因素.

关键词:
这就是BRCA1的原因.这种风格仍然存在.乳腺癌 乳腺癌 乳腺癌细胞分裂是细胞分裂的过程.中心体的中心体是什么

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