儿童暴露对健康的影响:系统性审查
Rasaq Yusuf1, Phoka C Rathebe1
1Faculty of Health Sciences, Department of Environmental Health, University of Johannesburg, Doornfontein Campus, P.O. Box 524, Johannesburg 2006, South Africa.
Children (Basel, Switzerland)
|February 27, 2026
概括
儿童暴露于会增加肺癌的风险,并导致生物变化. 这一系统性审查强调了对儿童的累积影响.
科学领域:
- 环境健康 环境健康
- 儿科瘤学 儿科瘤学
- 毒理学 毒理学 毒理学
背景情况:
- 暴露是肺癌的已知危险因素之一.
- 儿童独特的生理学增加了他们对的有害影响的脆弱性.
- 诱导癌症的长潜伏期可能会掩盖儿童的早期发病率.
研究的目的:
- 综合当前关于儿童暴露对健康的影响的证据.
- 调查儿科群体中暴露与肺癌风险之间的关联.
- 为了识别与童年暴露相关的生物标志物.
主要方法:
- 1994年至2025年间发表的定量研究的系统审查.
- 在CINAHL,PubMed,谷歌学者,ScienceDirect和EBSCOhost进行的搜索.
- 使用GRADE评估研究质量;遵循PRISMA检查表;注册在PROSPERO (ID:CRD420251269394) 上.
主要成果:
- 儿童暴露在统计学上与肺癌发病率的增加有关 (每100Bq/m3的OR=1.16).
- 国际白素-5 (IL-5) 被确定为与长期儿童暴露相关的生物标志物 (13.4%的增加,p=0.044).
结论:
- 儿童暴露在中有助于累积终身肺癌风险.
- 儿童暴露于会导致可检测的生物变化,即使明显的恶性瘤是罕见的.
- 需要进一步的研究,以充分了解暴露对儿童健康的长期影响.
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