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患儿多发性硬化症不同并发症类别的患病率,发病率和风险:系统审查和元分析协议

Sara Samadzadeh^1,2, Moein Mirzai³, Aysan Valinejad Qanati³

¹Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.

Children (Basel, Switzerland)

|February 27, 2026

概括

本系统性审查综合了儿科发病多发性硬化症 (POMS) 相关疾病的证据,旨在改善年轻多发性硬化症患者的临床结果. 结果将指导POMS的查和管理策略.

科学领域:

神经学神经学
儿科神经学儿科神经学
流行病学流行病学

背景情况:

儿科发病的多发性硬化症 (POMS) 与成人发病的多发性硬化症有着不同的,往往比成人发病的多发性硬化症更为繁重的病程.
同病症显著影响MS的进展和结果,但它们在POMS中的作用尚不清楚.
没有全面的系统审查评估了POMS群体的并发症.

研究的目的:

系统地识别和综合有关POMS相关疾病的流行,发病率和风险的证据.
描述这些并发症及其对疾病过程和治疗结果的影响.
为POMS.提供临床管理和未来研究方向的信息.

主要方法:

系统审查和对MEDLINE (PubMed) 和Embase. 的元分析.
没有日期限制的搜索,使用受控的词汇和关键词对POMS和15种并发症类别进行搜索.
独立审查员选,数据提取和随机效应模型元分析,如果可能的话;描述性合成,否则.

主要成果:

该研究将系统量化POMS的并发症流行,发病率和风险.
它将分析POMS特定的并发症特征及其对临床结果的影响.
共同疾病的综合流行率将是主要的定量结果.

结论:

这一审查将为POMS并发症管理建立一个关键的证据基础.
预计这些发现将指导查方案,并完善儿科MS的管理策略.
最终目标是改善患有MS的儿童和青少年的临床结果和生活质量.

关键词:

临床结果的临床结果.这种疾病是共患的.疾病的进展疾病的进展发生率的发生率.进行元分析.小儿多发性硬化症儿科发作的多发性硬化症 (POMS)患病率的流行情况.危险的风险危险的风险系统性审查系统性审查

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