周围动脉疾病 (P.A.D. ):使用印刷电路板 (PCB) 设计进行血管血液动力学模拟
Claudiu N Lungu1, Aurelia Romila1, Aurel Nechita1
1Faculty of Medicine and Pharmacy, Medical and Pharmaceutical Research Center, Dunarea de Jos University, 8000080 Galati, Romania.
Bioengineering (Basel, Switzerland)
|February 27, 2026
概括
一个低成本的印刷电路板 (PCB) 模拟模型动脉狭窄动脉动力学实时. 这种电路提供了一种有价值的,直观的工具,用于研究由逐渐缩小引起的血管阻抗变化.
科学领域:
- 生物医学工程 生物医学工程
- 电气工程 电气工程
- 流体动力学 流体动力学
背景情况:
- 动脉狭窄导致血管阻抗的复杂,非线性变化.
- 实时调查在当前的基准或计算流体动力学 (CFD) 模型中是很困难的.
研究的目的:
- 开发一个低成本的印刷电路板 (PCB) 模拟.
- 使用R-L-C电气元件复制渐进性动脉狭窄的血液动力学效应,以映射血管力学.
主要方法:
- 构建了一个一次性参数电网,其中电压代表压力,电流代表流量.
- 使用可变电阻模拟焦点狭窄,逐渐调整逐渐狭窄.
- 使用已确定的电子元件与血管特性之间的关系来确定生理对应 (例如,R=8μl/πr4).
主要成果:
- 模拟PCB显示出输出电压和峰值到峰值电压的单调上升,模拟狭窄的增加.
- 观察到一个明显的拐点超出中等范围的缩小,与理论压力损失预测一致.
- 定性趋势与0D和CFD分析相匹配,轻度狭窄症的变化最小 (≤25%),中度至重度狭窄症的急剧增加 (≥50%).
结论:
- 该PCB模拟器有效地实时复制动脉狭窄的血液动力学特征,并且成本低.
- 为教育和研究提供了有价值的工具,使血管行为的快速可视化成为可能.
- 未来的工作将改进校准,量化不确定性,并根据生理测量和CFD模拟进行验证.
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