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从高血压前期到高血压的进展和胃肠癌的风险 - 全国健康查队列研究

Hyejin Yoon¹, Jiyu Sun², Dong-Woo Choi¹

¹Cancer Big Data Center, National Cancer Control Institute, National Cancer Center, Goyang-si 10408, Republic of Korea.

|February 27, 2026

概括

从高血压前期到高血压的进展增加了胃肠道癌症的风险,特别是结肠直肠癌和胰腺癌. 管理血压可能会减少癌症负担.

科学领域:

心血管健康心血管健康
胃肠道瘤学胃肠道瘤学
流行病学流行病学

背景情况:

高血压是一种已知的心血管疾病风险因素,与胃肠道 (GI) 癌症有关.
高血压前期和胃肠道癌症风险之间的关系尚未得到充分证实.
这项研究研究了从高血压前期到高血压的进展对肠道癌症风险的影响.

研究的目的:

调查前高血压向高血压的进展与患肠道癌症的风险之间的关联.
为了确定与这种进展相关的特定的胃肠道癌症类型.
探索影响这种关联的因素,包括年龄,糖尿病状况和药物坚持.

主要方法:

对韩国预高血压患者健康查队列的分析.
根据两次血压测量,对参与者进行了分类,分为正常血压,持续性高血压前期和进展到高血压的组.
利用因果特定的考克斯比例危险模型,并对暴露窗口,延迟时间和药物坚持进行敏感性分析.

主要成果:

高血压的进展与整体胃肠道癌症风险增加有关 (aHR 1.16).
在结直肠和胰腺癌中观察到更强烈的关联.
风险在年轻人 (<65岁),没有糖尿病的人以及药物坚持较低的人中更为明显.

结论:

防止从高血压前期发展为高血压可能会降低肠胃癌的长期负担.
早期检测和管理高血压,特别是高药物坚持,可以减轻未来的胃肠道癌症风险.
这些发现强调了血压管理在癌症预防策略中的重要性.

关键词:

血压的轨迹血压的轨迹癌症的风险癌症的风险队列研究是一项队列研究.这是胃肠道癌症.药物治疗的坚持药物治疗的坚持

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