重温OGIPRO试验:与HER2-阳性乳腺癌中的EQ-5D-5L相比,动态电子患者报告的结果
Anatol Aicher1, Marcus Vetter2,3, David Blum1,4
1Medical Faculty, University of Zurich, 8006 Zurich, Switzerland.
Cancers
|February 27, 2026
概括
关于幸福感的动态电子患者报告结果 (ePRO) 与EQ-5D-5L视觉模拟量表密切一致,验证了它们在瘤学中的使用. 然而,ePRO症状数据与EQ-5D-5L领域的一致性较弱,需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 数字健康数字健康
- 卫生经济学 卫生经济学
背景情况:
- 患者报告的结果 (PROs) 对于评估癌症治疗耐受性和生活质量至关重要.
- 动态电子PRO (ePRO) 提供高频纵向数据,但它们与EQ-5D-5L等既有措施的对齐不清楚.
- 这项研究调查了HER2阳性乳腺癌患者的ePRO数据和EQ-5D-5L之间的一致性.
研究的目的:
- 评估动态ePRO幸福度评分与EQ-5D-5L视觉模拟量表 (VAS) 之间的对齐.
- 评估聚合的ePRO症状等级与EQ-5D-5L域得分和无用性之间的一致性.
- 确定ePROs作为EQ-5D-5L在临床和研究环境中的替代品的实用性.
主要方法:
- 对前性OGIPRO试验 (KEK-ZH 2021-D0051) 数据的回顾性分析.
- 利用线性混合效应建模分析了来自53名HER2阳性乳腺癌患者的13699个动态ePRO数据点.
- 与EQ-5D-5L VAS和EQ-5D-5L域和不实用性比较了ePRO幸福感和ePRO症状等级.
主要成果:
- 动态 ePRO 幸福感与 EQ-5D-5L VAS (β = 1.061) 强烈一致,这表明患者间的差异性很低.
- 综合的ePRO症状等级和EQ-5D-5L域/不实用性之间的一致性在患者之间较弱和更异质 (分别为β = 0.404和β = 0.213).
结论:
- 动态ePRO幸福感是EQ-5D-5LVAS在瘤学研究和临床实践中的有效替代品.
- 汇总的ePRO症状数据与EQ-5D-5L领域的一致性有限,这表明需要更细致的分析和更大的数据集.
- 动态的ePRO系统为患者监测和人工智能驱动的精密瘤学决策支持提供了可扩展的基础.
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