关于粒子辐射的临床证据,DNA损伤反应抑制剂,以及针对不匹配修复能力强的直肠癌的免疫疗法
Cristian J Salazar-Vilches1, Daniel K Ebner1, Jake A Kloeber1
1Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Cancers
|February 27, 2026
概括
颗粒疗法和DNA损伤反应抑制剂 (DDRi) 在pMMR结肠直肠癌中显示出临床前的前景,增强免疫疗法反应. 结合这些模式的临床试验有限,但由于潜在的益处和毒性问题,需要进一步调查.
科学领域:
- 辐射瘤学 辐射瘤学
- 免疫治疗是一种免疫疗法.
- 结肠直肠癌研究研究
背景情况:
- 对pMMR结肠直肠癌的颗粒疗法,DDRi和免疫疗法的系统审查.
- 专注于2014-2025年临床和临床前文献.
研究的目的:
- 评估粒子疗法,DDRi和免疫疗法在pMMR结直肠癌中的疗效和安全性.
- 为了确定这些联合治疗方式的临床研究的差距.
主要方法:
- 在主要数据库中进行系统的文献审查.
- 包括单独或与DDRi/ICI结合的粒子放射治疗 (质子,α,碳) 的研究.
- 包括X射线放射治疗 (XRT) 与DDRi/ICI结合使用.
主要成果:
- 包括133项研究,其中62项是临床研究.
- 颗粒疗法显示出出色的局部控制和组织节省,可控的毒性.
- 很少有试验将辐射与DDRi结合在一起;ICI组合与XRT显示出希望.
结论:
- 颗粒辐射和DDRi在pMMR直肠腺癌中具有临床前免疫刺激作用.
- 结合这三种方式的临床试验很少.
- 存在潜在的益处,但具有毒性监测的前性评估至关重要.
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