威尔德的免疫和瘤微环境机制:一个范围审查和网络药理学分析
Soo-Dam Kim1, Eun Soo Park2, Jung Hyang Park2
1KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Cancers
|February 27, 2026
概括
扩散 (HDW) 通过调节瘤微环境 (TME) 和免疫反应来表现出抗瘤作用. 网络分析显示PI3K-Akt-STAT3信号是其治疗潜力的关键机制.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 瘤微环境 (TME) 对癌症的进展和治疗耐药性至关重要.
- 红 (Hedyotis diffusa,HDW) 是东亚传统药物,据报道具有抗炎和抗癌的功效.
- HDW对TME和免疫系统的作用机制需要系统的合成.
研究的目的:
- 系统地审查关于HW对抗瘤活性,免疫力和TME的影响的临床前证据.
- 进行网络药理学分析,以阐明HDW的生物活性化合物,点和信号通路.
- 将实验发现与系统层面的分析相结合,以全面了解HDW的治疗机制.
主要方法:
- 根据PRISMA-ScR指南,对临床前研究 (2016-2025) 的范围审查.
- 网络药理学分析,包括化合物识别,目标预测和途径丰富.
- 蛋白质与蛋白质相互作用分析,绘制信号网络的地图.
主要成果:
- 59项研究证实HDW能够抑制瘤增殖,诱导亡和铁亡,抑制EMT和血管生成,并增强抗瘤免疫力.
- HDW减弱了与瘤相关的炎症.
- 网络分析确定了94个与免疫和TME相关的目标,突出了PI3K-Akt,STAT3,EGFR和SRC信号网络,这些网络参与了关键的癌症途径.
结论:
- HDW作为一种具有直接细胞毒性,免疫激活性和TME重塑性质的多目标植物药物.
- 调节PI3K-Akt-STAT3信号通路是 HDW 所观察到的影响的核心机制.
- 通过整合各种生物作用,HDW具有作为癌症治疗剂的潜力.
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