相关实验视频

Updated: Feb 28, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

母亲多 (I:C) 诱导的胎盘炎症和内分泌功能障碍与小鼠后代的皮质生殖中断有关

Catherine Zhou¹, Callan Baldwin¹, Shuying Lin²

¹Summer Undergraduate Research Program, University of Mississippi Medical Center, Jackson, MS 39216, USA.

|February 27, 2026

概括

怀孕期间由感染引起的孕产妇免疫激活 (MIA) 可以导致儿童出现自闭症谱系障碍 (ASD). 这项研究表明,MIA破坏了胎盘功能,增加了大脑炎症并改变了后代的神经发育.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
发育生物学发展生物学

背景情况:

母亲免疫激活 (MIA) 是自闭症谱系障碍 (ASD) 的已知危险因素.
胎盘通过免疫和激素调节在胎儿大脑发育中发挥着至关重要的作用.
了解MIA如何影响胎盘功能和随后的神经发育至关重要.

研究的目的:

研究MIA如何改变胎盘细胞因子,免疫细胞组成和内分泌输出.
检查这些胎盘变化与后代神经炎症和神经发生的关系.

主要方法:

怀孕的小鼠被暴露在多氨酸:多乙烯酸 (poly(I:C)) 中以诱导MIA.
分析了胎盘巨细胞,中性粒细胞,细胞因子和神经生长因子 (NGF).
对后代的大脑进行了微质活动和神经生成标志物的评估.

主要成果:

MIA导致胎盘单细胞,中性粒细胞和胎盘和羊水中的炎症性细胞因子增加.
在MIA后,胎盘NGF水平显著降低.
MIA诱导了持续的微质激活,并破坏了后代大脑中的皮质神经发生.

结论:

在MIA期间增强的Th17炎症信号传递有助于神经发育变化.
胎盘内分泌功能受损,特别是NGF减少,在失调的神经发生过程中起作用.
这些胎盘变化将MIA与胎儿大脑发育的改变和ASD风险的增加联系起来.

关键词:

自闭症谱系障碍自闭症谱系障碍神经前代细胞的神经前代细胞神经发生神经发生.神经炎症是一种神经炎症.它们的扩散和扩散.

更多相关视频

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...