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在健康志愿者的运动活动中通过皮肤进行神经刺激:高密度扩散光学断层扫描研究

Sheharyar S Baig¹, Caitlin H Illingworth¹, Breanna McQueen²

¹Sheffield Institute for Translational Neuroscience, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2HQ, UK.

|February 27, 2026

概括

高密度扩散光学断层扫描 (HD-DOT) 可以记录经皮耳迷走神经刺激 (taVNS) 期间的大脑活动. 这项研究发现,HD-DOT可用于监测taVNS对运动任务的影响,这表明中风恢复生物标志物的潜力.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
康复医学康复医学康复医学

背景情况:

卒中是全球残疾的主要原因之一.
通过皮肤进行耳道迷走神经刺激 (taVNS),有助于神经可塑性和运动恢复.
目前缺乏taVNS的验证生物标志物.

研究的目的:

评估高密度扩散光学断层扫描 (HD-DOT) 是否可以在并发taVNS期间检测与运动任务相关的大脑活动.
探索HD-DOT作为taVNS效应的生物标志物的潜力.

主要方法:

31名健康参与者用假和活跃的taVNS进行了手指敲击任务.
高密度扩散光学断层扫描 (HD-DOT) 监测了双边的感觉运动皮层活动.
与任务相关的血液动力学变化与taVNS条件进行了比较.

主要成果:

在运动任务中,HD-DOT成功检测到预期的横向感应运动激活.
在右手点击的活跃和虚假taVNS之间没有观察到与任务相关的激活的显著差异.
在使用主动taVNS的左手点击时,观察到活动再分配的无意义趋势.

结论:

在运动任务中同时使用HD-DOT和taVNS是可行的,并且被很好地容忍.
HD-DOT可靠地记录了与任务相关的皮质激活.
需要对中风患者进行未来的研究,以验证HD-DOT作为taVNS生物标志物.

关键词:

扩散光学断层扫描 (DFT) 是一种扩散光学断层扫描.功能近红外光谱学近红外光谱学非侵入性大脑刺激康复康复康复康复康复康复一次性中风中风中风中风中风迷走神经刺激迷走神经刺激

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