快速眼动 (REM) 睡眠中的言语和语言变化与潜在的诊断标记:系统性审查
Maria Pagano1, Francesco Corallo1, Anna Anselmo1
1IRCCS Centro Neurolesi Bonino-Pulejo, Via Palermo, S.S. 113, C.da Casazza, 98124 Messina, Italy.
Brain sciences
|February 27, 2026
概括
语音和声音变化可能标志着REM睡眠行为障碍 (RBD),这是一种与帕金森病相关的疾病. 这些变化可以作为神经退行性疾病的早期,非侵入性生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 语言病理学 语音病理学
- 睡眠医学 睡眠医学
背景情况:
- 快速眼动 (REM) 睡眠行为障碍 (RBD) 是一种与神经退行相关的睡眠障碍,特别是像帕金森病这样的α-synucleinopathies.
- 目前用于RBD的诊断生物标志物往往是侵入性的或昂贵的.
- 了解早期的非侵入性标志物对于及时诊断和干预至关重要.
研究的目的:
- 研究声声和语音变化作为REM睡眠行为障碍 (RBD) 的潜在探索性生物标志物.
- 评估早期神经退行性发言和声音变化的诊断和预后潜力.
主要方法:
- 根据PRISMA 2020指南进行了系统审查,搜索主要的科学数据库.
- 包括十二项符合预先定义的选择标准的研究,并进行了定性质量评估.
- 分析了RBD患者的发音和语音模式,包括表音,发音,时间和发音.
主要成果:
- 患有RBD的个体表现出异常的夜间发音,以及词汇,语法和叙事语言的中断.
- 定量分析揭示了前奏,声调稳定性,时间和发音方面的持续缺陷,诊断准确度高 (高达96%的灵敏度).
- 数字表型检测检测出新出现的帕金森症标志,AUC>0.70,表明随着时间的推移进展.
结论:
- 在异常性RBD (iRBD) 中的言语和声音异常反映了早期的神经退行过程.
- 这些声音标记物显示出有希望的,尽管仍在探索,对于诊断和预测同核蛋白病变的进展潜力.
- 需要进一步的研究来验证可靠的语音特征,以便早期检测出发性同核蛋白病变.
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