生活方式因素在多发性硬化症中的作用:综合性视角
Roberta Lanzillo1,2, Marinella Clerico3,4, Saverio Stranges5,6,7,8
1Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80138 Naples, Italy.
Brain sciences
|February 27, 2026
概括
生活方式的选择显著影响多发性硬化症 (MS) 风险和进展. 饮食,睡眠和运动等可改变的因素在治疗多发性硬化和改善患者的治疗结果方面发挥着至关重要的作用.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是一种慢性,免疫媒介的神经疾病.
- 遗传因素有助于MS风险,但生活方式因素越来越被认为至关重要.
- 了解可修改的生活方式影响是MS管理的关键.
研究的目的:
- 审查生活方式因素对多发性硬化症发病,活动和进展的影响.
- 探索将生活方式与MS联系在一起的生物机制.
- 为了确定MS管理的潜在补充策略.
主要方法:
- 来自PubMed,Scopus和谷歌学者文学作品的叙事评论.
- 搜索词包括"生活方式和多发性硬化症"",饮食和多发性硬化症"",睡眠和多发性硬化症"",酒精消费和多发性硬化症"和"体力活动和多发性硬化症".
主要成果:
- 肥胖,特别是在青春期,是通过免疫代谢途径发生多发性硬化症的重要危险因素.
- 睡眠障碍有助于神经炎症和认知功能障碍.
- 吸烟加快MS残疾;过度饮酒会影响睡眠和淋巴功能.
结论:
- 生活方式因素 (饮食,睡眠,运动,物质使用) 汇聚在影响MS的共同途径上.
- 将生活方式咨询与疾病修饰疗法相结合可能会优化MS的结果.
- 在翻译和临床环境中需要进一步的研究.
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