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Updated: Feb 28, 2026

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胸前动脉动脉瘤的发展取决于膜类型-1矩阵金属蛋白酶的活性和丰度

Ying Xiong1, Rupak Mukherjee1, Sarah L Lieser1

  • 1Department of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Biomolecules
|February 27, 2026
PubMed
概括

纤维细胞衍生的膜类型-1矩阵金属蛋白酶 (MT1-MMP) 通过激活TGF-β信号,影响细胞外矩阵重塑和大动脉扩张,驱动胸前大动脉动脉瘤 (TAA) 的发展.

关键词:
TGF-β 中和抗体治疗药物纤维细胞细胞是什么?膜类型-1矩阵金属蛋白酶.胸前大动脉动脉瘤是什么?

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