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在肥胖中调节和重编程脂肪组织巨细胞

Yan Liu¹, Xiaoying Huang¹, Linfeng Sang¹

¹Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei 230032, China.

|February 27, 2026

概括

肥胖引起的慢性炎症涉及脂肪组织巨细胞 (ATM) 和它们的代谢途径的重新编程. 本综述详细介绍了ATM代谢变化和肥胖相关炎症和功能障碍的调节机制.

科学领域:

免疫学免疫学免疫学
代谢过程中的代谢.
肥胖问题研究研究

背景情况:

肥胖与慢性炎症有关,导致代谢功能障碍.
脂肪组织巨细胞 (ATM) 是脂肪组织中的关键免疫细胞,在肥胖中介于炎症.
ATM的异质性和功能是代谢失调的核心.

研究的目的:

审查肥胖症中ATM的代谢重编程.
突出ATM在慢性代谢炎症中的作用.
讨论调节ATM重塑在肥胖中的机制.

主要方法:

文献综述侧重于ATM中的代谢途径.
分析ATM的转录和表观遗传调节.
综合当前关于肥胖中ATM功能的研究.

主要成果:

在肥胖症中,ATM经历了显著的代谢途径重编程.
改变ATM中的葡萄糖和脂质平衡有助于炎症.
转录和表观遗传因素推动了ATM的改造.

结论:

ATM代谢重编程是肥胖引起的炎症的一个关键因素.
了解这些机制可以为代谢疾病的治疗策略提供信息.
准ATM新陈代谢为管理与肥胖相关的并发症提供了潜力.

关键词:

脂肪组织的脂肪组织.巨细胞是什么?巨细胞是什么?代谢重编程是指代谢重编程.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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