抗生素后多种共生补充促进了微生物多样性和功能的恢复,并增加了肠道屏障的完整性:一个随机的,安慰剂控制的试验
Brooke A Napier1, Jessica R Allegretti2, Paul Feuerstadt3,4
1Seed Health, Inc., Venice, CA 90291, USA.
这项研究表明,多种共生菌有助于在抗生素治疗后恢复肠道微生物群的多样性和功能. 它改善了有益的微生物,代谢物和肠道屏障完整性,有助于从抗生素相关症状中恢复.
科学领域:
- 微生物组研究的研究.
- 肠道健康 肠道健康
- 临床试验中的临床试验.
背景情况:
- 抗生素对感染至关重要,但会破坏肠道微生物组及其功能.
- 益生菌使用后抗生素的临床结果是不一致的,因为产品的变化和不清楚的机制.
- 这项研究旨在澄清特定协生菌在抗生素治疗期间和之后对肠道微生物群和屏障功能的影响.
研究的目的:
- 研究一种多种共生菌 (DS-01) 对肠道微生物组合和功能的影响.
- 评估协生菌对接受抗生素的健康成年人肠道屏障完整性的影响.
- 评估微生物组依赖的代谢物变化和安全概况.
主要方法:
- 一个91天的随机,安慰剂控制试验,涉及健康成年人.
- 参与者每天接受一种协同生物或安慰剂,以及七天的西普罗夫洛克萨和美特罗尼达疗程.
- 终点包括便微生物组分析,代谢物水平 (乙酸盐,丁酸盐,乌罗利thin A,p-cresol硫酸盐),肠道屏障完整性和多个时间点的安全评估.
主要成果:
- 这种共生菌显著增加了Bifidobacterium和Lactobacillus的α多样性,并增强了有益微生物的恢复,包括酸盐生产者.
- 关键的有益代谢物,如便中的丁酸盐和酸盐,以及尿液中的乌罗立A,显著增加.
- 与安慰剂相比,有害的p-cresol硫酸盐水平下降,肠道屏障完整性迅速和长期改善.
结论:
- 多种共生菌有效促进肠道微生物群多样性的恢复和抗生素后有益的微生物.
- 它有助于恢复微生物组依赖的代谢物,并增强肠道屏障功能.
- 这些效应表明,共生菌有潜力减轻与抗生素相关的胃肠道症状.
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