西班牙Clostridioides difficile的抗菌敏感性:多中心回顾性队列研究
María-Paz Ventero1, María-Dolores Valverde-Fredet2, Esperanza Merino3,4
1Microbiology Service, Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.
Antibiotics (Basel, Switzerland)
|February 27, 2026
概括
在西班牙的一项研究中,克洛斯特里迪奥伊德复杂菌对美特罗尼达,万科米辛和tigecycline的耐药性并不常见. 菲达克索米辛和埃拉瓦环素在体外表现出极好的活性,总体上耐药性率较低.
科学领域:
- 临床微生物学 临床微生物学
- 传染病 传染病 传染病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 困难菌感染 (CDI) 构成了重大的公共卫生挑战.
- 了解抗微生物敏感性对于有效的CDI治疗至关重要.
- 关于西班牙CDI队列中耐药性概况的数据有限.
研究的目的:
- 为了在体外确定C. difficile分离物对关键抗生素的敏感性.
- 为了评估多中心西班牙队列中的抵抗模式.
- 评估耐药性与临床因素之间的关联.
主要方法:
- 从西班牙患者中收集C. difficile分离物的前景采集 (NCT04801862).
- 使用E-试验和亚格稀释的抗菌敏感性测试.
- 根据EUCAST断点和ECOFF标准解释结果.
主要成果:
- 对万科米辛 (2.8%),提格环素 (2.8%) 和美特罗尼达 (1.9%) 观察到的耐药率较低.
- 菲达克索米辛 (0.9%) 和埃拉瓦环素显示出极少或没有耐药性.
- 在耐药性和临床因素 (如严重程度或复发) 之间没有发现显著的关联.
结论:
- 菲达克索米辛和埃拉瓦环素在体外对C. difficile有强烈的活性.
- 虽然不常见,但可以检测到对美特罗尼达,万科米辛和tigecycline的耐药性.
- 持续监测抗菌素耐药性及其临床影响至关重要.
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