与多药耐药细菌和真菌感染的出现相关的危险因素 在隔离性胰腺缩中
Michael Fernandez Y Viesca1, Alia Hadefi1, Lukas Otero Sanchez1
1Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Antibiotics (Basel, Switzerland)
|February 27, 2026
概括
抗生素变化和营养支持增加了多药耐药 (MDR) 细菌在感染胰腺缩 (IPN) 的风险. 真菌感染没有特定的风险因素,但MDR病例的ICU入院率更高.
科学领域:
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
- 临界护理医学 临界护理医学
背景情况:
- 感染性胰腺亡 (IPN) 是急性胰腺炎 (AP) 的严重并发症,导致高发病率和死亡率.
- 管理涉及抗生素和排水,但多药耐药 (MDR) 细菌和真菌感染 (FI) 带来越来越大的挑战.
- 对MDR出现的风险因素和FI在IPN的影响需要进一步调查.
研究的目的:
- 确定IPN干预期间MDR细菌出现的独立风险因素.
- 探索与IPN患者的真菌感染 (FIs) 相关的风险因素.
- 分析MDR细菌和FI对患者结局的影响,包括重症监护室 (ICU) 的入院.
主要方法:
- 这是一项追溯研究,对71名连续接受IPN或症状隔离性瘤 (WON) 干预的患者进行了追溯研究.
- 在初始和随后的干预中分析微生物数据 (MDR细菌,广泛耐药 (XDR) 细菌和FI).
- 统计分析以确定MDR出现和FI的独立风险因素,并比较不同患者组的结果.
主要成果:
- 在干预后,IPN在73%的患者中得到证实;MDR/XDR细菌和FI分别在35%/15.5%和59%的患者中检测到.
- 对MDR出现的独立风险因素包括抗生素变化的数量 (p=0.004) 和需要营养支持 (NS) (p=0.010).
- 没有与FI相关的独立风险因素. 与非IPN和非MDR组相比,IPN (63.1%) 和MDR (72.2%) 病例的ICU入院率显著更高.
结论:
- 抗生素变化的数量和需要营养支持的需要独立地与IPN中MDR细菌的出现有关.
- 在这个患者队列中,没有特定的独立风险因素被确定为真菌感染.
- 在IPN患者和感染MDR细菌的患者中观察到更高的ICU入院率,突出显示了这些疾病的严重程度.
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