具有抗氧化和抗炎性质的Parthenocissus quinquefolia的生物活性成分:系统性审查
Álvaro Becerra1, Felipe Soto1, Alejandro Vallejos1
1Escuela de Fonoaudiología & Departamento de Ciencias Químicas y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago 8370854, Chile.
Antioxidants (Basel, Switzerland)
|February 27, 2026
概括
帕特诺西斯昆奎福利亚 (Parthenocissus quinquefolia) 或弗吉尼亚爬虫,含有强大的化合物,显示出显著的抗氧化和抗炎作用. 这种植物对开发针对氧化应激和炎症的新植物疗法充满希望.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
背景情况:
- 在智利,Parthenocissus quinquefolia (维吉尼亚蔓延植物) 广泛使用,但缺乏其生物活性化合物的全面表征.
- 专注于调节氧化还原平衡和炎症的代谢物.
研究的目的:
- 系统地审查P. quinquefolia的植物化学成分.
- 综合其抗氧化和抗炎生物活性的证据.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 在四个电子数据库中对抗氧化和抗炎作用的研究进行了搜索.
- 包括来自665个识别记录的14项研究.
主要成果:
- 已识别的化合物,包括黄类化合物 (例如,奎尔塞丁,鲁丁) 和类化合物 (例如,e-viniferin).
- 通过反应性氧物种 (ROS) 清除,金属化和Nrf2/ARE通路激活来证明抗氧化活性.
- 通过降低NF-κB,AP-1和MAPK信号的调节,NLRP3炎症酶抑制和COX-2/iNOS.抑制表现出抗炎作用.
结论:
- 昆奎叶植物 (P. quinquefolia) 富含具有强烈抗氧化和抗炎性能的代谢物.
- 一致的分子机制支持其植物治疗发展的潜力.
- 突出了针对氧化应激和炎症通路的潜力.
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